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Martin Bohm, is a widower and single father who is haunted by an inability to connect to his emotionally challenged 11-year-old son Jake. But when Martin discovers that Jake can predict events before they happen, everything changes. Martin meets social worker Clea Hopkins and Professor Arthur Teller who may have the keys to help unlock Jake’s mind.

Martin is led to a pawn shop by his son Jake, where a robbery triggers a sequence of unpredictable events that connect a distraught flight attendant in New York, a son visiting from India on a mission to spread his father’s ashes, a middle school magician in Moscow, a cancer patient in New York and a mobster in the Bronx. It’s up to Jake and Martin to link the thread between them all.

When Martin comes in contact with a homeless man who possesses the same obsession with numbers as Jake, he sets out on a series of seemingly unrelated tasks that connect an abused African woman, a group of African boys entering a dance competition and an outgoing woman at California’s famed Coachella Valley Music and Arts Festival. Meanwhile, Teller pays a visit to Jake’s board-and-care facility and emotions run high for Clea.

Martin crosses paths with a young man who has a history with his deceased wife, Sarah. A couple managing an online instrument repair business work with an Iraqi heavy metal band that has a teenage follower who is looking to share his comedic talent with an American soldier in Baghdad. But the soldier has troubles of her own when her convoy is ambushed, forcing her to hide in the Iraqi desert. Then, a lottery winner comes upon a depressed pastor.

Martin gets his laptop stolen on the day Jake is scheduled for an important evaluation. As a result, he becomes ensnared in a young Salvadoran woman’s quest to avenge the death of her family. Meanwhile, Teller tries to reconnect with his estranged daughter. Also, a spirited Saudi Arabian girl tries to break free of the societal constraints imposed on her and a Montreal doctor attempts to meet a stranger on a train.

As Martin and Clea work together to uncover a shocking development involving Clea’s mentally-challenged mother, Teller steps into trouble when he visits Jake at the board-and-care facility. Meanwhile, a plane crash survivor seeks new purpose to his existence and a Chinese couple struggles to find balance between work and life.

Not knowing what life holds for them once they reach Los Angeles, Martin and Jake, on the run from the authorities, immediately meet Lucy Robbins, Amelia's mother, upon their arrival. Lucy has been looking for her daughter now for three years, and is encouraged by her meeting with Martin. However, their relationship may not be totally harmonious as Lucy will do absolutely anything in order to track down Amelia.

Martin and Lucy become aware of the importance of Calvin Norburg in finding Amelia. As it is near impossible to get close to Calvin due to this publicity, Martin and Trevor believe the best way to gain access to Calvin is through Vikash. Although Martin does manage to gain access to Vikash, he finds that he must first assist Vikash on his latest personal mission.

Martin’s mission to uncover clues and expose the potentially sinister Aster Corps has global consequences when an Aster Corps employee is crossing the border in Pakistan. Meanwhile, ruthless religious zealot Guillermo continues to track down "The Righteous 36", and Jake leads Lucy to a woman with alarming connections to her missing daughter Amelia.

Unforeseen developments at Aster Corps force Martin to make a nail-biting decision and strike a deal with someone unexpected. Meanwhile, Lucy visits the police with new information about Amelia’s kidnapping and Avram (guest star Bodhi Elfman) spots Guillermo in New York and warns Martin and Jake that he’s on the hunt for them.

A race against time is triggered after Jake contacts Amelia with coordinates to a meeting location and both manage to escape their supervision. As Martin and Lucy desperately search for their gifted and determined kids, they uncover some critical details about Calvin’s brain-damaged brother. Meanwhile in Mexico, Guillermo confesses his sins to a priest and faces a brutal decision.

After three years of searching for Amelia, Lucy’s frustration and fury peaks. When she takes matters with Calvin into her own hands, he offers an unthinkable deal for Amelia’s return. As Martin and Jake search for Lucy, they enlist Trevor at Breakwire to help. Meanwhile, Guillermo is reeling from his recent sins in Mexico, and he makes some life-changing decisions after running into a defeated man hiking through the Arizona desert.